Synthesis of morpholino nucleosides starting from enantiopure glycidol
نویسندگان
چکیده
A rapid synthesis of morpholino monomers from readily available building blocks is reported.
منابع مشابه
Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade.
Styrene monooxygenase (SMO) can catalyze the kinetic resolution of secondary allylic alcohols to provide enantiopure glycidol derivatives. To overcome the low theoretical yield of kinetic resolution, we designed a one-pot two-step enzymatic cascade using prochiral α,β-unsaturated ketones as the substrates. An S-specific ketoreductase ChKRED03 was screened for the efficient bioreduction of the s...
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Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The applicatio...
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The single-handedness of biological molecules is critical for molecular recognition and replication processes and would seem to be a prerequisite for the origin of life. A drawback of recently reported synthetic routes to RNA is the requirement for enantioenriched reactants, which fails to address the puzzle of how the single chirality of biological molecules arose. Here, we report the synthesi...
متن کاملCytidine nucleosides II. Photochemical synthesis of 5-alkylcytidine nucleosides
5-Alkylcytidine nucleosides were synthesized via a photocoupling reaction. 5-Propylcytidine and 5-propyl-2-deoxycytidine have been prepared through the reduction of 5-(3-propenyl)cytidine and its 2'-deoxy derivative, which in turn were prepared by photoirradiation of cytidine or 2'-deoxycytidine in the presence of 3-iodopropene. 5-(2-Hydroxyethyl)cytidine and its derivatives were obtained from ...
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ژورنال
عنوان ژورنال: Organic chemistry frontiers
سال: 2022
ISSN: ['2052-4110', '2052-4129']
DOI: https://doi.org/10.1039/d2qo00400c